University of Chicago Center for EPR Imaging in Vivo Physiology
University of Chicago

P41 Consortium

University of Chicago
University of Denver
University of Maryland
NIOC, Novosibirsk 
UIUC 

PI:  Howard J. Halpern
co-PI:  Gareth R. Eaton [DU center]
co-PI:  Gerald M. Rosen [site]
co-PI: Victor M. Tormyshev
co-PI: Zhi-Pei Liang [site]

 

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Welcome to the  Center for Electron Paramagnetic Resonance (EPR) Imaging in Vivo Physiology at the University of Chicago, a National Institutes of Biomedical Imaging and Bioengineering, NIH, supported Technology Development Resource.  The aim of the Center is the development of new imaging technologies sensitive to the functioning of the normal and diseased tissues of living animals. The Center's imaging technology exploits the unique, quantitative sensitivity of the EPR spectrum of soluble, injectable spin probes to crucial aspects of the fluids in which life processes evolve. The Center develops EPR instrumentation, spin probes and imaging methodologies. We use very low frequency EPR technology to maximize the depth in animal tissue to which the technique is sensitive. We have developed a wide range of methodologies to extract this information including pulse, continuous wave and Rapid Scan methodologies.

EPR imaging is used in the preclinical studies of tissue microenvironment, including oxygen partial pressure, pH and redox potential. This information is crucial for understanding of cancer physiology, radiological treatment improvement, study of stroke, heart attack, peripheral vascular disease and other biomedical problems.

The Center is a consortium between the University of Chicago, the University of Denver, the University of Maryland and Novosibirsk Institute of Organic Chemistry (NIOC), Russia. The University of Chicago develops and validates technology. EPR instrumentation and methodology is developed in Denver. University of Maryland designs and syntheses nitroxide microenvironment sensitive spin probes and spin traps. NIOC develops novel oxygen sensitive trityl spin probes.

The resources of the Center are committed to:

  • Research and development of novel biomedical EPR imaging technologies
  • Stimulation of collaborative research projects
  • Provision of service, routine measurements with aspects of the unique technology available through the Center
  • Training and education of members of the scientific community in the use of the novel technologies
  • Dissemination of the technologic advances

 

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